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Does Influenza Vaccination Reduce AFib Risk?
Influenza vaccination was associated with lower risks of incident atrial fibrillation (AFib) and multiple cardiovascular outcomes, according to an observational cohort study published July 11 in EHJ. The findings support vaccination as a potential AFib prevention strategy and underscore the need for randomized trials focused on AFib-related outcomes.
In the large retrospective study, Laurent Fauchier, MD, et al., used the international TriNetX Global Collaborative Federated Research Data Network, which included adults with a routine health care visit in 2022. Vaccination exposure was defined as influenza vaccination within the preceding year vs. no recorded vaccination.
Researchers performed 1:1 propensity score matching across 65 baseline variables to assess incident AFib, cardiovascular events and mortality, with subgroup analyses by age and baseline cardiovascular disease. The matched cohort included 276,888 patients in two well-balanced groups of 138,444 each (mean age, 53 years; 57% women).
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