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College football betting: Should you take LSU and the points at Clemson?
The 2025 college football season kicks off with one of the biggest nonconference matchups of the year as LSU travels to Death Valley to face Clemson.
With potential early College Football Playoff implications and Heisman considerations, Clemson opens as a 4.5-point favorite at home, leaning on continuity and experience, while LSU brings elite talent and one of the most dynamic quarterbacks in the country.
With both offenses built to move the ball and plenty of unknowns on defense, this matchup sets up to be one of the most compelling Week 1 showdowns.
LSU Tigers vs. Clemson Tigers (-4.5)
Saturday, 7:30 p.m. ET, ABC
LSU vs. Clemson prediction, pick, odds, spread, where to watch live
The battle of the Tigers — and the real Death Valley — has as good an argument as any as the best game of Week 1 of the 2025 college football season.
Sure, there's no Arch Mania or defending national champion involved like that game in Columbus. But the stakes are sky high and there will be NFL talent all over the field Saturday night in Clemson when Dabo Swinney's No. 4 Clemson Tigers take on Brian Kelly's No. 9 LSU Tigers.
Clemson is coming off a quarterfinal finish in last year's College Football Playoff and should have the pieces on both sides of the ball to be a legitimate national title contender this season. Clemson has three players — quarterback Cade Klubnik, defensive tackle Peter Woods and defensive end T.J. Parker — projected to be top 10 picks in CBS Sports' most recent mock draft.
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