Red Sox vs. Phillies odds, line, prediction, time: 2025 MLB picks, best bets for July 21 by prove…

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Red Sox vs. Phillies odds, line, prediction, time: 2025 MLB picks, best bets for July 21 by proven model

The Boston Red Sox will look to stay hot as they face the Philadelphia Phillies in a key interleague matchup on Monday night. Boston is coming off a 6-1 win over the Chicago Cubs, while Philadelphia dropped an 8-2 decision to the Los Angeles Angels on Sunday. The Red Sox (54-47), third in the American League East, have won eight of their last 10 games. The Phillies (56-43), first in the National League East, have dropped six of 10.

First pitch from Citizens Bank Park in Philadelphia is set for 6:45 p.m. ET. The Red Sox have won four of the last six meetings with the Phillies, including two in a row. Philadelphia is a -228 favorite on the money line (risk $228 to win $100) in the latest Red Sox vs. Phillies odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 8. Before making any Red Sox vs. Phillies picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

Game 102: Red Sox at Phillies lineups and notes

After dropping two of three to a Cubs squad that is tied for first in the NL Central, the Red Sox will take on another first-place team when they open a series with the NL East-leading Phillies.

The Sox managed to avoid a sweep at Wrigley Field when they rallied for a 6-1 win on Sunday, thanks to a pair of home runs from Wilyer Abreu and a three-run, pinch-hit homer from Alex Bregman. Abreu had gone 1 for 12 with six strikeouts over his previous five games.

Walker Buehler will get the nod for Monday’s opener at Citizen’s Bank Park. After struggling in June, Buehler has had a bit of a bounce back in July, allowing just two earned runs in five innings in a win over the Nationals, as well as a six-inning performance in which he yielded three runs in a game the Red Sox went on to defeat the Rays.

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