Phillies vs. Nationals prediction, odds, start time: 2025 MLB picks, best bets for August 22 by p…

Explore the latest developments concerning Phillies vs. Nationals.

Phillies vs. Nationals prediction, odds, start time: 2025 MLB picks, best bets for August 22 by proven model

The Philadelphia Phillies will look to extend their winning streak to five games when they take on the Washington Nationals in the first of a three-game series on Friday night. Philadelphia is coming off a three-game sweep of the Seattle Mariners, while Washington won two of three games against the New York Mets. The Nationals (52-75), who are fifth in the National League East, are 27-36 on the road this season. The Phillies (74-53), who are first in the NL East, are 40-21 on their home field in 2025.

First pitch from Citizens Bank Park in Philadelphia is set for 6:45 p.m. ET. The Phillies have won six of the past 10 meetings with the Nationals. Philadelphia is a -191 favorite on the money line (risk $191 to win $100) in the latest Nationals vs. Phillies odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 9. Before making any Nationals vs. Phillies picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model. New users can also target the DraftKings promo code, which offers $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

Game 128 lineups: Nats at Phillies

PHILADELPHIA – How about that surprising homestand? The Nationals wound up going 4-3 against the Phillies and Mets, looking pretty sharp in the process against the top two teams in the division. So what’s up next? How about a road trip to … Philadelphia and New York!

They won’t be facing the Mets again; this trip concludes at Yankee Stadium, not Citi Field. But first up, it is a rematch with the Phillies over the weekend, the Nats hoping to keep the good vibes going in a very familiar matchup.

Cade Cavalli looked great six nights ago against this same lineup, tossing seven scoreless innings on 90 pitches to earn his first major league win. It’s an entirely new challenge, though, to face the same team again, especially in back-to-back starts. Surely, the Phillies picked up on something about Cavalli in the first meeting. It’s up to the rookie right-hander (and the Nationals coaching staff) to figure out what, if any, adjustments he needs to make in the rematch.

Phillies Open Up Nats Series a -185 Favorite Behind Cy-Juan Walker

Get ready for a whole boat load of NL East baseball.

Seventeen of the Phillies’ next 20 games come against divisional foes, starting with Friday’s clash against the Nationals.

The Phillies are 18-14 in NL East play so far this season and a few days removed from the split of a four-game series with the Nats down in D.C.

Friday’s game, in which the Phils are a -185 money line favorite, gives us the exact same pitching matchup from last Saturday, with Taijuan Walker going up against Cade Cavalli.

Walker and Cavalli combined to give up 13 hits, but each hurler pitched into the seventh inning. The Nats actually won that game 2-0, but there are numbers from that contest that we can use for Friday.

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