Explore the latest developments concerning Cubs vs. Rays.
Cubs vs. Rays prediction, odds, time: 2026 MLB picks for Monday, April 6 from proven model
The Chicago Cubs take on the Tampa Bay Rays in an interleague matchup in Tampa Bay's home opener on Monday afternoon. Chicago is coming off a doubleheader split with the Cleveland Guardians, winning 1-0 and losing 6-5, while Tampa Bay defeated Minnesota 4-1 on Sunday. The Cubs (4-5), who finished second in the National League Central at 92-70 a year ago, were 42-39 on the road. The Rays (4-5), who finished fourth in the American League East in 2025, were 41-40 on their home field.
First pitch Tropicana Field in St. Petersburg, Fla., is set for 4:10 p.m. ET. Tampa Bay is a -124 favorite on the money line (risk $124 to win $100) in the latest Cubs vs. Rays odds, while the over/under is 8. Before making any Rays vs. Cubs picks, be sure to see the Cubs vs. Rays predictions and betting advice from SportsLine's proven computer model.
Chicago Cubs vs. Tampa Bay Rays preview, Monday 4/6, 3:10 CT
IT’S STILL EARLY: April 6 is the earliest date on which the Cubs have played the Rays. The previous earliest was April 18, in 2022, at Wrigley Field. The earliest at Miami was June 11 in 2024, the last time the Cubs journeyed there. The Cubs’ first games this season vs. the Angels and Guardians also were their earliest in those rivalries. (Courtesy BCB’s JohnW53)
HOME RUNS ARE GOOD, BUT… The Cubs have lost the last three games in which they hit exactly three home runs: on Sept. 25 of last year, at home against the Mets, 8-5; on March 29, at home against the Nationals, 6-3; and yesterday in Game 2 at Cleveland, 6-5. Before that, they had lost only three of 19 three-homer games, going back to Sept. 30, 2023. (Courtesy BCB’s JohnW53)
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How to watch Cubs vs. Rays: TV channel and streaming options for April 6
The Tampa Bay Rays and Chicago Cubs clash on Monday at 4:10 p.m. ET, beginning a three-game series at Tropicana Field. Shane McClanahan (0-1, 3.86 ERA) will start for the Rays, who are 4-5 this season and second in the AL East. Jameson Taillon (0-0, 0.00 ERA) is the expected starter for the Cubs, who are 4-5 and fifth in the NL Central.
Gavin Lux: 10 Day IL (Shoulder), Ryan Pepiot: 15 Day IL (Hip), Garrett Cleavinger: 15 Day IL (Calf), Edwin Uceta: 15 Day IL (Shoulder), Manuel Rodriguez: 60 Day IL (Elbow), Steven Wilson: 60 Day IL (Back)
Seiya Suzuki: 10 Day IL (Knee), Porter Hodge: 15 Day IL (Elbow), Jordan Wicks: 15 Day IL (Forearm), Cade Horton: 15 Day IL (Forearm), Justin Steele: 60 Day IL (Elbow), Shelby Miller: 60 Day IL (Elbow), Christopher Austin: 60 Day IL (Knee)
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